Abstract
The aim of the present study was to investigate the incidence of sleep disturbance and insomnia in patients with primary hyperparathyroidism (PHPT), and to evaluate the effect of parathyroidectomy. A questionnaire was prospectively administered to adult patients with PHPT who underwent curative parathyroidectomy over an 11-month period. The questionnaire, administered preoperatively and 6months postoperatively, included the Insomnia Severity Index (ISI) and eight additional questions regarding sleep pattern. Total ISI scores range from 0 to 28, with >7 signifying sleep difficulties and scores >14 indicating clinical insomnia. Of 197 eligible patients undergoing parathyroidectomy for PHPT, 115 (58.3%) completed the preoperative and postoperative questionnaires. The mean age was 60.0±1.2years and 80.0% were women. Preoperatively, 72 patients (62.6%) had sleep difficulties, and 29 patients (25.2%) met the criteria for clinical insomnia. Clinicopathologic variables were not predictive of clinical insomnia. There was a significant reduction in mean ISI score after parathyroidectomy (10.3±0.6 vs 6.2±0.5, p<0.0001). Postoperatively, 79 patients (68.7%) had an improved ISI score. Of the 29 patients with preoperative clinical insomnia, 21 (72.4%) had resolution after parathyroidectomy. Preoperative insomnia patients had an increase in total hours slept after parathyroidectomy (5.4±0.3 vs 6.1±0.3h, p=0.02), whereas both insomnia patients and non-insomnia patients had a decrease in the number of awakenings (3.7±0.4 vs 1.9±0.2 times, p=0.0001). Sleep disturbances and insomnia are common in patients with PHPT, and the majority of patients will improve after curative parathyroidectomy.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have