Abstract
The exact cause of liver failure occurring after long standing biliary obstruction is not known. Impairment of hepatic mitochondrial respiration was postulated in some studies. Sodium thiosulphate (STS) is known to have a protective effect on liver function during administration of hepatotoxic chemotherapy. In the present experimental study the effect of treatment with STS in the presence of obstructive jaundice was studied by determination of the survival rate of rats subjected to biliary obstruction and by polarographic determination of the hepatic mitochondrial function. Treatment with STS was found to result in a significant improvement in rats' survival rate (p < 0.05). Polarography demonstrated significant preservation of mitochondrial respiratory capacity after treatment with STS. The results of the present study show that the deterioration in liver function in the presence of biliary obstruction is probably caused by impairment of mitochondrial respiration. This may be preserved by treatment with STS. The exact explanation of its effect is not yet clear.
Highlights
MATERIAL AND METHODSDevelopment of hepatic failure in the presence of longstanding obstructive jaundice, its pathophysiology and possible prevention still focuses the attention of surgeons and other specialists
The mortality began in Group 2 (BDL only) on the third week after Bile duct ligation (BDL) and in Group 3
It can In our experimental study, impairment of liver be clearly seen that treatment with Sodium thiosulfate (STS) preserved most mitochondrial function was demonstrated in biliary of the mitochondrial respiratory functions in rats sub- obstruction
Summary
MATERIAL AND METHODSDevelopment of hepatic failure in the presence of longstanding obstructive jaundice, its pathophysiology and possible prevention still focuses the attention of surgeons and other specialists. Administration on the survival rate and liver mitochondrial respiratory function in rats subjected to biliary obstruction. Mitochondrial respiratory function assay was performed in group 1 (n 10 rats), group 2 (n 12 rats) and group 3 (n 34 rats)[6] four weeks after BDL or sham operation.
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