Abstract
In the article, the results of diagnostics and treatment of 30 men aged 30–45 (mean age 36.2 ± 5.3 years) with chronic nonbacterial prostatitis (CNP) and male factor infertility in marriage are presented. Among the patients, 15 patients had CNP and secretory infertility (1st group; mean age 35.2 ± 4.3 years), 15 men with infertility caused by CNP and varicocele in the postoperative period (2nd group; mean age 33.6 ± 3.3 years). Duration of the male factor infertility varied from 1 to 4.5 years, and on average it was 2.8 ± 1.6 years. After detailed questioning and examination, including a spermiogram, determination of antisperm antibodies, DNA fragmentation test, and electron microscopy of the ejaculate, patients in the 1st group received Prostatilen AC as rectal suppositories for 10 days. Patients in the second group received Prostatilen AC in the form of rectal suppositories for 20 days. We showed an improvement of quality of life and spermatogenesis characteristics with decreased MAR test (more pronounced in the 2nd group), a decrease in the DNA fragmentation index, and an improvement in ultrastructural morphofunctional characteristics of spermatozoa. We justify the use of Prostatilen AC to increase effectiveness of assisted reproductive technologies in men in programs of preconception preparation to fatherhood.
Highlights
Improvement of quality of life and morphofunctional characteristics of spermatozoa in men with chronic nonbacterial prostatitis and in a program of preconception preparation to fatherhood
15 patients had chronic nonbacterial prostatitis (CNP) and secretory infertility (1st group; mean age 35.2 ± 4.3 years), 15 men with infertility caused by CNP and varicocele in the postoperative period (2nd group; mean age 33.6 ± 3.3 years)
We showed an improvement of quality of life and spermatogenesis characteristics with decreased MAR test, a decrease in the DNA fragmentation index, and an improvement in ultrastructural morphofunctional characteristics of spermatozoa
Summary
Из них 15 больных с ХАП и секреторным типом бесплодия (1-я группа; средний возраст 35,2 ± 4,3 года), 15 мужчин с бесплодием, обусловленным ХАП и варикоцеле в послеоперационном периоде (2-я группа; средний возраст 33,6 ± 3,3 года). После тщательного анкетирования и обследования, включая спермограмму, определение антиспермальных антител, тест на фрагментацию ДНК, электронное микроскопическое исследование эякулята, больные 1-й группы получали Простатилен АЦ в виде суппозиториев ректальных в течение 10 дней. Ключевые слова: мужское бесплодие, хронический абактериальный простатит, варикоцеле, MAR-тест, индекс фрагментации ДНК, электронное микроскопическое исследование эякулята, Простатилен АЦ, спермограмма. After detailed questioning and examination, including a spermiogram, determination of antisperm antibodies, DNA fragmentation test, and electron microscopy of the ejaculate, patients in the 1st group received Prostatilen AC as rectal suppositories for 10 days. Нарушение фертильности у мужчин оценивают как многофакторное состояние, которое может быть связано с тем, что есть органические изменения 35 см 40 см гонадизм, крипторхизм и т. д.) органов половой системы, оно способно возникать вследствие функциональной патозооспермии при хроническом абактериальном
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