Abstract
With the completion of the Human Genome Project and beginning of post genome era, there is an urgent need for a fast, specific, sensitive, reliable and cost-effective method for the genome-wide polymorphism analysis. Microarray technology is one of the most promising approaches to this need. There are two major concerns in the microarray technology; one is target labeling and the other is the reliability of single nucleotide mismatch discrimination. In this chapter, we reported our recent progress in molecular beacon arrays for detecting label-free targets and a microarray based melting-curve analysis method for improving the reliability of single nucleotide mismatch discrimination. Several successful practical applications of these improved microarray technologies have also been illustrated.
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