Abstract
Optimized stent pattern design can effectively enhance the mechanical performance of magnesium alloy stents by adjusting strain distribution and evolution during stent deformation, thereby overcoming the limitations imposed by the intrinsic mechanical properties of magnesium alloys. In the present study, a new stent design pattern for magnesium alloys was proposed and compared to two existing stent design patterns. Measures of the mechanical performance of these three stents, including crimping and expanding deformability, radial scaffolding capacity, radial recoil and bending flexibility, were determined. Three-dimensional finite element (FE) models were built to predict the mechanical performance of the stents with the three design patterns and to assist in understanding the experimental results. The results showed that, overall, the stent with the new design pattern was superior to the stents based on the existing designs, though the expanding capacity of the newly designed stent still needed to be improved.
Highlights
Bioresorbable coronary artery stents are clinically desired to provide temporary scaffolding to narrowed blood vessels, thereby allowing the restoration of biological functions to the blood vessels, wherein the stents can be absorbed after vessel restoration [1]
The results showed that the rate of strength loss during biodegradation mostly depended on the hinge circumferential width, rather than on the material properties of the alloy or the cross-section shape of the stent
Strain distributions in unit A and unit B at a displacement of 0.1 mm revealed by the Finite element analysis (FEA) are Strain in unit A andstrain unit B
Summary
Bioresorbable coronary artery stents are clinically desired to provide temporary scaffolding to narrowed blood vessels, thereby allowing the restoration of biological functions to the blood vessels, wherein the stents can be absorbed after vessel restoration [1]. Previous studies on coronary artery stents made of bioresorbable polymers showed promising results from the clinical trials [2]. The bioresorbable poly(L-lactide) (PLLA) vascular scaffold system became the first type of bioresorbable coronary artery stents approved by the U.S Food and Drug Administration (FDA). In view of the desired mechanical performance of a coronary artery stent, bioresorbable magnesium alloys are considered more attractive, because magnesium alloys have a higher elastic modulus and a higher strength than polymers.
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