Abstract
Fewer studies compared the improvement of plasma lipid levels after different types of surgery, in particular compared to one-anastomosis gastric bypass (OAGB). The aim of our study was to investigate how laparoscopic sleeve gastrectomy (LSG) and OAGB impact on weight loss and lipid profile 18 months after surgery, in patients with severe obesity. Forty-six patients treated with OAGB were matched to eighty-eight patients submitted to LSG. Weight loss after OAGB (33.2%) was more evident than after LSG (29.6%) (p = 0.024). The difference in the prevalence of dyslipidemia showed a statistically significant reduction only after OAGB (61% versus 22%, p < 0.001). After adjustment for delta body mass index (BMI), age and sex, we demonstrated a statistically significant decrease of the differences between the changes before and after (delta Δ) the two surgery procedures: Δ total cholesterol values (p < 0.001), Δ low density lipoprotein-cholesterol values (p < 0.001) and Δ triglycerides values (p = 0.007). Patients with severe obesity undergoing to OAGB presented a better improvement of lipid plasma values than LSG patients. The reduction of lipid plasma levels was independent of the significant decrease of BMI after surgery, of age and of sex.
Highlights
Several studies have shown the efficacy of bariatric surgery, in terms of weight loss, and remission from type 2 diabetes mellitus (T2DM) and decrease of cardiovascular risk [1].The most commonly performed procedure is laparoscopic sleeve gastrectomy (LSG), followed by Roux-en-Y gastric bypass (RYGB) [2]
We demonstrated that plasma lipid levels decrease more after One anastomosis gastric bypass (OAGB) compared to LSG, in patients with similar preoperative characteristics, independently of age, sex and the reduction of body mass index (BMI)
A systematic review and metaanalysis to examine the effectiveness and risks of bariatric surgery showed that randomized control trials displayed 76% remission of dyslipidemia after surgery and in observational studies, the remission rate was 68% [7]
Summary
Several studies have shown the efficacy of bariatric surgery, in terms of weight loss, and remission from type 2 diabetes mellitus (T2DM) and decrease of cardiovascular risk [1].The most commonly performed procedure is laparoscopic sleeve gastrectomy (LSG), followed by Roux-en-Y gastric bypass (RYGB) [2]. Several studies have shown the efficacy of bariatric surgery, in terms of weight loss, and remission from type 2 diabetes mellitus (T2DM) and decrease of cardiovascular risk [1]. The efficacy and safety of OAGB versus RYGB for obesity has been demonstrated in the YOMEGA study [4]. A systematic review and meta-analysis to examine the effectiveness and risks of bariatric surgery showed that only few studies investigated dyslipidemia outcome; more than two thirds out of the patients included in these studies showed remission of dyslipidemia after surgery [7]. Several studies compared outcomes of different surgical procedures in terms of weight loss, complications, quality of life and remission of comorbidities, in particular T2DM, hypertension and obstructive sleep apnea [8,9,10,11,12]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
