Abstract
A bitter stomachic powder, named NGD powder, has been prepared at our hospital. However, a questionnaire survey conducted by the Japanese Society of Hospitai Pharmacists reveals that elderly patients complain of difficulty in taking this formula because of its bitter taste and dustiness. Therefore, we attempted to reformulatier this NGD powder in tablet form and to study the pharmaceutical properties of the subsequently produced NGD tablets. Microcrystalline cellulose (MCC) was added in amounts of 20%, 30% and 40% to its amount of NGD powder, and compressed using a compression force of 0.5, 1.0, 1.5 or 2.0 ton/cm2 These tablets were then examined for their crushing strength, friability, disintegration time, neutralizing capacity and amylosaccharifying activity. Moment analysis was carried out especially for the neutralizing capacity of the tablets. Optimum regression equations were obtained using multiple regression analysis for each of the characteristics. The results suggest that the optimum amount of MCC and compression force are 30% and 1.0 ton/cm2, respectively.
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