Abstract
Hair graying is a common age-related hair change with tremendous social and cosmetic concerns among aged individuals. Many mechanisms contribute to hair graying, such as defective melanocyte stem cell renewal, melanocyte apoptosis, and melanocyte migration defects. Accumulation of oxidative stress has been regarded as a key factor influencing these processes. However, currently, there is no standard treatment for reversing hair graying. Herein, we report our observation of improvement of hair graying in a patient with male pattern hair loss during combined treatment with 1,927-nm fractionated thulium laser energy and intra-perifollicular polydeoxyribonucleotide injections. The patient showed increased numbers of pigmented hair follicles and clinical improvement in hair graying after 12 sessions of combined treatment. Accordingly, we suggest that the combined treatment described in this report may be a promising therapeutic method for treating hair graying.
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