Abstract
BackgroundPre-diabetes is a disturbing trend in the population, who are at risk of developing type-two diabetes. The aim of this study was to determine the effects use of Aloe vera in different doses on glucose and lipid profile in pre-diabetic subjects.MethodsThis study was a double blind randomized controlled trial (72 subjects) with pre-diabetes symptoms in 3 groups consumed capsules twice a day: Aloe vera 300 mg (AL300), 500 mg (AL500) and placebo (PL). Fasting blood glucose (FBS), HbA1C and lipid profile were evaluated in baseline, 4 or 8 weeks. On-way ANOVA, Friedman, Wilcoxon, Kruskal-Wallis , Mann–Whitney and Chi-square tests were used for within or between groups statistical analysis.ResultsFBS level in group AL300, showed significantly decreased in fourth week after the intervention, compared to PL in the same time (p = 0.001). Also, HbA1C level in this group at the eighth week after the intervention (p = 0.042), had a significant decrease. The levels of Total cholesterol and LDL-C, only in the group AL500 (p < 0.001 and p = 0.01), was significantly reduced, along with HDL-C level improvement just after eight weeks (p = 0.004). Triglyceride level showed a significant decrease (p < 0.045) just after four weeks use of AL500.ConclusionsThe Use of Aloe vera extract in pre-diabetic patients, could revert impaired blood glucose within four weeks, but after eight weeks could alleviate their abnormal lipid profile.
Highlights
Pre-diabetes and metabolic syndrome, which follows it, are parts of interrelated common clinical disorders that are accompanied by symptoms of obesity, insulin resistance, glucose intolerance, lipid abnormalities, impaired fasting glucose, and Impaired glucose tolerance (IGT) [1]
Some studies have reported that approximately 5-10% of pre-diabetic population would suffer from diabetes and problems associated with it in around a year such as heart problems, imbalance in glucose and lipid metabolism, and vascular disorders
This study was done on 72 volunteers who were selected according to entry criteria including an age between 35 to 65 years; fasting blood glucose between 100 and 125 mg/dl; HbA1C between 5.7 to 6.4; TG between 200–150 mg/dl; CHOL-C between 250–200 mg/dl; HDL-C less than 35 mg/dl; LDL-C between 130–160 mg/dl; BMI between 25–30; no use of any lipid-lowering treatment and no has any serious stress during last two months
Summary
Pre-diabetes and metabolic syndrome, which follows it, are parts of interrelated common clinical disorders that are accompanied by symptoms of obesity, insulin resistance, glucose intolerance, lipid abnormalities, impaired fasting glucose, and Impaired glucose tolerance (IGT) [1]. Some studies have reported that approximately 5-10% of pre-diabetic population would suffer from diabetes and problems associated with it in around a year such as heart problems, imbalance in glucose and lipid metabolism, and vascular disorders. Interventions in this population can preserve pancreatic beta cells, and improve their. Aloe (Aloe vera L., Liliaceae family) has applications in health and cosmetic products as well as antioxidant, anticancer, anti-inflammatory, laxative, anti-atherosclerosis properties It includes 75 active components that contain vitamins, enzymes, minerals, sugars, Lignin, salicylic acid, and amino acids [6,7]. The aim of this study was to determine the effects use of Aloe vera in different doses on glucose and lipid profile in pre-diabetic subjects
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
