Abstract
An attempt was made to improve the release property of nifedipine (NP) from Witepsol® H-15, glycerin and polyethylene glycol (PEG) suppository bases by means of the complexation with 2-hydroxypropyl-β-cyclodextrin (HP-β-CyD). The amorphous complexes of NP with HP-β-CyD in molar ratios of 1:1–1:10 (guest:host) were prepared by the spray-drying method. The NP/HP-β-CyD complex was homogeneously dispersed in Witepsol® H-15 suppository base, whereas the drug alone and the physical mixture of the guest and host were sedimented at the bottom of the base. The release rates of NP from Witepsol® H-15 and glycerin suppositories were significantly increased by the complexation with HP-β-CyD. On the other hand, HP-β-CyD gave negligible effect on the release rate of NP from PEG suppository base. The results indicated that Witepsol® H-15 suppository containing NP/HP-β-CyD complex is useful from a viewpoint of the release control and quality assurance.
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