Improvement of Diastolic Function in Patients With Congestive Heart Failure After Cardiac Resynchronization Therapy by Echocardiography

Abstract

Brief Description of the Purpose of the StudyThe aims were to evaluate the diastolic function in CHF after CRT by conventional echocardiography or Doppler tissue imaging (TDI) and supply information for clinical therapy.Methods31 patients with CHF were divided into responders (Group R) and non-responders (Group R) according standard of a decline in LV end-systolic volume ≥10% 6 months after CRT. All the patients received echo examination 1-3 days before CRT and 6 month after CRT. Color M-mode echocardiography indices included Vp, E/Vp. TDI indices included the peak velocity in early diastole (e) at 4 sites of mitral annulus, E/e, time to peak velocity in systole (Ts), Ts-SD and maximum difference of Ts (Ts-Dif) among 12 segments.Main ResultsCompared with before CRT, Ts-SD and Ts-Dif significantly shortened in Group R; Vp increased significantly, E/e at each 4 site and mean value at 4 sites of mitral annulus, E/Vp decreased significantly; but there were no significant difference in Group N. There were significant positive correlation between mean value at 4 sites of E/e, E/Vp and Ts-SD in Group R.Importance of the ConclusionsThe diastolic function in responders to CRT improved, which was associated with the decreased LV filling pressure and improved LV relaxation. Brief Description of the Purpose of the StudyThe aims were to evaluate the diastolic function in CHF after CRT by conventional echocardiography or Doppler tissue imaging (TDI) and supply information for clinical therapy. The aims were to evaluate the diastolic function in CHF after CRT by conventional echocardiography or Doppler tissue imaging (TDI) and supply information for clinical therapy. Methods31 patients with CHF were divided into responders (Group R) and non-responders (Group R) according standard of a decline in LV end-systolic volume ≥10% 6 months after CRT. All the patients received echo examination 1-3 days before CRT and 6 month after CRT. Color M-mode echocardiography indices included Vp, E/Vp. TDI indices included the peak velocity in early diastole (e) at 4 sites of mitral annulus, E/e, time to peak velocity in systole (Ts), Ts-SD and maximum difference of Ts (Ts-Dif) among 12 segments. 31 patients with CHF were divided into responders (Group R) and non-responders (Group R) according standard of a decline in LV end-systolic volume ≥10% 6 months after CRT. All the patients received echo examination 1-3 days before CRT and 6 month after CRT. Color M-mode echocardiography indices included Vp, E/Vp. TDI indices included the peak velocity in early diastole (e) at 4 sites of mitral annulus, E/e, time to peak velocity in systole (Ts), Ts-SD and maximum difference of Ts (Ts-Dif) among 12 segments. Main ResultsCompared with before CRT, Ts-SD and Ts-Dif significantly shortened in Group R; Vp increased significantly, E/e at each 4 site and mean value at 4 sites of mitral annulus, E/Vp decreased significantly; but there were no significant difference in Group N. There were significant positive correlation between mean value at 4 sites of E/e, E/Vp and Ts-SD in Group R. Compared with before CRT, Ts-SD and Ts-Dif significantly shortened in Group R; Vp increased significantly, E/e at each 4 site and mean value at 4 sites of mitral annulus, E/Vp decreased significantly; but there were no significant difference in Group N. There were significant positive correlation between mean value at 4 sites of E/e, E/Vp and Ts-SD in Group R. Importance of the ConclusionsThe diastolic function in responders to CRT improved, which was associated with the decreased LV filling pressure and improved LV relaxation. The diastolic function in responders to CRT improved, which was associated with the decreased LV filling pressure and improved LV relaxation.