Improvement of cognition by enhancing neurogenesis and neuronal plasticity with a CNTF peptidergic compound

Abstract

synergistically increased brain phosphatides, synaptic proteins, and dendritic spines formation (Wurtman, 2009). The Fortasyn Connect multi-nutrient concept improved membrane integrity, thereby influencing membrane-dependent processes such as receptor function and amyloid precursor protein processing, as shown by reduced Abeta production and plaque burden, as well as Abeta toxicity (Kamphuis, 2009). This multi-nutrient supplementation may also have neuroprotective effects by reducing lipid-peroxidation and vascular damage. Conclusions: Together, these insights provided the basis for the development of Souvenaid , a multi-nutrient drink for patients with AD containing Fortasyn Connect, and designed to enhance synapse formation in AD. The effect of Souvenaid on memory and cognitive performance was recently assessed in a proof-of-concept study, Souvenir I, with 212 drug-naive mild AD patients (MMSE 20-26). The study showed that oral nutritional supplementation with Souvenaid given for 12 weeks improves memory in patients with mild AD (Scheltens, 2010). To confirm and extend these findings, three additional studies were initiated. Two studies will be completed in 2011 and one study will be completed in 2013.