Abstract
Background: The calcium signaling derangements found in heart failure (HF) have been associated with a decrease in the calcium-handling protein S100A1. Overexpression of S100A1 has been shown to improve normal myocyte contractility in vitro. This study evaluates the ability of adenoviral mediated S100A1 transgene delivery to improve cardiomyocyte performance in a pacing model of porcine HF. Methods: Adult pigs were paced at a rate of 220 beats per minute. At two weeks, HF was confirmed by echocardiography.
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