Abstract
The effect of oral application of Ginkgo biloba extract EGb 761 ® on auditory discrimination learning in Mongolian gerbils was investigated using discrimination tasks with three different degrees of difficulty and two protocols for administration starting 2 weeks prior to or at the beginning of training. In comparison to placebo-treated controls we observed significant improvement of learning performance in EGb 761 ® treated gerbils in discrimination tasks of all degrees of difficulty, from the easiest to the most demanding. EGb 761 ® has been reported to increase the extracellular concentration of dopamine in prefrontal cortex of rats which plays a major role in the type of discrimination learning used in the present study. We, therefore, suppose that EGb 761 ® improves discrimination learning through its effect on the dopaminergic system.
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