Abstract
Artemisinin, a sesquiterpene lactone; is one of the most well–known secondary metabolites with multi–functional therapeutic effects which is isolated from Artemisia annua. Due to low levels of artemisinin in this plant, efforts are being made to optimize its production by various strategies such as elicitation–infiltration. This is a procedure in which, elicitors are injected to the plants by fine–needles directly. In this study, we identified the effect of bacterial and fungal elicitors on artemisinin level and biomass accumulation in A. annua. Artemisinin content was measured by high performance thin layer chromatography. The maximum level of artemisinin was accomplished by injection of 0.4 mg total sugar/ml F. oxysporum and B. cereus decreased artemisinin content in comparison to the controls. 1 McFarland S. aureus was the most successful elicitor, increasing the fresh weight 1.34 fold over the controls.
Highlights
IntroductionThe plant– derived chemicals were a significant source for pharmaceuticals [SHAKERAN et al, 2015]
Since ancient times, the plant– derived chemicals were a significant source for pharmaceuticals [SHAKERAN et al, 2015]
Artemisinin, a sesquiterpene lactone containing an endoperoxide bridge is isolated from Artemisia anuua L. plants
Summary
The plant– derived chemicals were a significant source for pharmaceuticals [SHAKERAN et al, 2015]. Many active constituents of medicinal, commercial and poisonous of plants belong to secondary metabolites. Sesquiterpenoid lactones are biologically active secondary metabolites of plants of Compositae family [HANDON et al, 2003]. Artemisinin, a sesquiterpene lactone containing an endoperoxide bridge is isolated from Artemisia anuua L. plants. This compound is effective against both drug–resistant and cerebral malaria causing strains of Plasmodium falciparum, different cancers and viruses [NAKASE et al, 2008, EFFERTH et al, 2008, ABDIN et al, 2003]. The low production (0.01–0.8%) of artemisinin in A. annua is the main obstacle to the commercialization of the drug. Various studies have been conducted to enhance the yield of this invaluable compound either in cell/tissue culture or in the whole plant of A. annua [ABDIN et al, 2003]
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