Abstract
目的 探讨针刺对快速老化痴呆模型小白鼠SAMP8认知功能的影响.方法选取SAMP8小鼠分为SAMP8对照组,针刺组,非穴组,并设SAMR1对照组.针刺组采用益气调血,扶本培元针法,针刺膻中、中脘、气海及双侧血海、足三里;非穴组取双侧胁下两个固定非经非穴点.应用Moms水迷宫观测各组小鼠空间参考记忆能力的变化,分析针刺对SAMP8小鼠认知功能的影响.结果与SAMR1对照组比较,SAMP8小鼠在隐蔽平台试验中表现出明显的学习记忆障碍,逃避潜伏期显著延长(P＜0.05).针刺组第5天的逃避潜伏期为(48.34±13.01)s,与SAMP8对照组比较显著缩短(P＜0.05);反向试验中第3天的逃避潜伏期为(55.03±15.49)s,比SAMP8对照组亦显著缩短(P＜0.05);探索试验中针刺组原平台象限的停留时间为(20.19±5.85)s,显著多于SAMP8对照组和非穴组(P＜0.05),与SAMR1对照组比较无显著差异.结论针刺可以改善快速老化痴呆模型小白鼠SAMP8的认知功能。
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