Abstract
Thunnus albacares (T.albacares) is plentiful with a promising research value and application. However, research on lipid-reducing activity and gut microbiota of T.albacares eggs yolk glycoprotein (TGP) remains unreported. In this work, we investigated the potential mechanism of TGP intervention to improve the disorders of lipid metabolism, and regulate gut microbiota in mice induced by high-fat diet (HFD). The results demonstrated that TGP improved the dyslipidemia, liver inflammation, and restored the liver tissue structure caused by HFD. TGP prevented lipid overaccumulation by downregulating the relative mRNA expression of lipid synthesis genes. TGP also prevented differential expansion of microbiota, increased the abundance of beneficial bacteria Lactobacillus and Akkermansia, and decreased the abundance of harmful bacteria Desulfovibrio. Moreover, TGP promoted the production of short-chain fatty acids (SCFAs). All the above results provided some theoretical basis for the in-depth development and application of TGP as a functional food for obesity and hyperlipidemia.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
