Improvement effect of short-term intensive insulin treatment on vascular endothelial function of diabetes patients

Abstract

Objective To study the improvement effect of short-term intensive insulin treatment on vascular endothelial function of diabetes patients. Methods Eighty diabetes patients from May 2012 to May 2013 were selected as the research objects, and they were divided into the observation group and the control group, with 40 cases in each group. The observation group received short-term intensive insulin treatment, and the control group was given oral antidiabetic drug. Fasting blood glucose (FBG), postprandial 2 h plasma glucose (2 h PPG), glycosylated hemoglobin (HbA1c), islet β-cell function (Homa-β), insulin resistance indexes (Homa-IR), nitric oxide (NO) and endothelin (ET), endothelium dependent vasodilatation function (FMEDD), non endothelium dependent diastolic function (NIEID) and other endothelial functions indexes in the two groups were compared. Results After treatment, FBG, 2 h PPG, HbA1c in the two groups decreased, and those of the observation group were significantly lower than those of the control group (P<0.05). The level of Homa-β in the observation group was significantly higher than that in the control group, and Homa-IR was significantly lower than that of the control group (P<0.05). The levels of NO [(35.53±9.56)mmol/L], FMEDD [(5.39±1.70)%] in the observation group were significantly lower than those of the control group [(29.86±7.16)mmol/L, (4.60±1.66)%], the level of ET [(55.34±7.65)mmol/L] was significantly lower than that of the control group [(70.85±9.23)mmol/L], P<0.05. Conclusions Short-term intensive insulin treatment for diabetes can preferably control blood glucose level of patients, protect the pancreatic β cells, improve the vascular endothelial cell function effectively, and has great clinical practice. Key words: Short-term intensive insulin; Diabetes; Vascular endothelial function