Abstract
Turbo spin echo (TSE) pulse sequences have been applied to estimate T(2) relaxation times in clinically feasible scan times. However, T(2) estimations using TSE pulse sequences has been shown to differ considerable from reference standard sequences due to several sources of error. The purpose of this work was to apply voxel-sensitivity formalism to correct for one such source of error introduced by differing phase encoding profile orders with dual-echo TSE pulse sequences. The American College of Radiology phantom and the brains of two healthy volunteers were imaged using dual-echo TSE as well as 32-echo spin-echo acquisitions and T(2) estimations from uncorrected and voxel-sensitivity formalism-corrected dual-echo TSE and 32-echo acquisitions were compared. In all regions of the brain and the majority of the analyses of the American College of Radiology phantom, voxel-sensitivity formalism correction resulted in considerable improvements in dual-echo TSE T(2) estimation compared with the 32-echo acquisition, with improvements in T(2) value accuracy ranging from 5.2% to 18.6%.
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