Abstract
The outcome of T-cell acute lymphoblastic leukemia (T-ALL) has improved with the use of pediatric-inspired protocols in the adolescents and young adults (AYA) population. There is limited literature regarding the outcome of T-ALL/lymphoblastic lymphoma (LBL) AYA patients treated with pediatric protocols. A total of 35 T-ALL/LBL-AYA patients ages between 14 and 55years were treated with AYA-15 protocol. At a median follow-up of 5years the overall survival, disease-free survivaland event-free survivalare 71%, 62% and 49.6% respectively. Toxicities were within the expected range. Our single-center experience real-world data in treating T-ALL/LBL-AYA patients with pediatric-inspired protocol demonstrates encouraging results of high survival rate and excellent tolerability for patients aged 18-55years.
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