Abstract
Honey has shown potential therapeutic properties in traditional medicine. This study investigated the cognition enhancing potential of Tualang honey in chronic cerebral hypoperfusion- induced neurodegeneration by permanent bilateral common carotid arteries ligation (2 vessels occlusion- 2VO) in rats. Previous studies have shown that rats subjected to 2VO (2 vessel occlusion) experienced cognitive deficits, oxidative stress and neuronal injury in the hippocampus of the brain. We studied the effect of Tualang honey on learning and memory using the Morris water maze (MWM) in rats. Rats were randomly divided into four groups (n=10); Sham control, untreated 2VO (2VO), honey treated 2VO (2VO+H) and honey treated group (H). Each group was again divided into two subgroups (n=5): one for long term memory assessment and another for short term memory and relearning tasks. After 10 weeks of treatment, all rat groups were tested for cognitive assessment by MWM (Morris water maze). 2VO+H rats had better spatial learning and memory performance than untreated 2VO rats in MWM tasks (p 0.05). This study shows that Malaysian Tualang honey might have therapeutic potential for the treatment of chronic cerebral hypoperfusion related neurodegenerative disorders such as Alzheimer’s disease (AD) in which cognitive impairment is profound.
Highlights
Neurodegenerative disorders including Alzheimer’s disease (AD) and dementia are associated with aging and reduced cerebral blood flow [1]
Reference memory performance: The spatial memory and learning assessment is demonstrated through Morris water maze performance
Chronic cerebral hypoperfusion animal model induced by permanent bilateral common carotid arteries occlusion demonstrated impaired spatial memory and learning on Morris water maze
Summary
Neurodegenerative disorders including Alzheimer’s disease (AD) and dementia are associated with aging and reduced cerebral blood flow [1]. Disturbances of the cerebral blood flow (CBF) have been correlated with the cognitive impairment in elderly people, as well as with the development of several types of dementia. Both dementia and cognitive decline are conditions associated with aging [1]. AD (Alzheimer’s disease) is an age-associated neurodegenerative disease that is characterized by a progressive impairment of memory and cognitive ability and other neurobehavioral manifestations due to loss of hippocampal and cortical neurons [2]. A large number of studies had been carried out, the cause of AD is still unknown
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