Abstract
Solid-state nanopores are attractive single-molecule biosensors but commonly suffer from low fabrication yield, poor repeatability, and weak signal-to-noise ratios as compared to biological protein-derived pores. Recent demonstrations of nanopore fabrication by dielectric breakdown in high electric fields offer a promising alternative to established methods which rely on electron microscopes or ion beams. Breakdown-derived nanopores can be fabricated on-demand in standard electrolytes, without need for vacuum systems or harsh chemicals. However, the stochastic and nonlinear nature of electrical breakdown introduces new challenges for achieving consistent sensor quality. We will present progress towards more reliable in situ formation of small-diameter solid-state nanopores, using self-limiting protocols that improve yield and avoid the runaway growth of nanopores in high electric fields.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
