Abstract
Improved preparation of C-aryl glucoside SGLT2 inhibitors
Highlights
Sodium glucose co-transporter 2 (SGLT2) plays a key role in maintaining glucose equilibrium in the human body.[1]
Much attention has been given to SGLT2 as a molecular target to directly induce glucose excretion and to safely normalize plasma glucose in the treatment of type 2 diabetes.[2]
The important intermediate 4 was prepared by Friedel-Crafts reaction but the selectivity of the ortho-position and para-position of the reaction was unsolved according to the procedure of William et al.[6]
Summary
Sodium glucose co-transporter 2 (SGLT2) plays a key role in maintaining glucose equilibrium in the human body.[1]. The reported synthetic route of 1 was shown in Scheme 1.5, 6
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
