Improved prediction of fellow-eye response in one-eye trials using multiple intraocular pressure measurements

Abstract

To examine the effects of multiple intraocular pressure (IOP) measurements on the correlation of response to glaucoma medication between fellow eyes. Latanoprost was applied to the first eye and then to both eyes of 16 patients with either primary open-angle glaucoma or ocular hypertension. IOP measurements were performed twice on different days for each of three periods: at baseline, during treatment of the first eye only and for both eyes. IOP decreases in the first and second eyes were evaluated with ∆IOP 1 (=IOP at baseline-IOP after treatment) and ∆IOP 2 (=∆IOP 1-IOP fluctuation of the contralateral eye). The correlation of IOP decreases between the fellow eyes was analyzed by linear regression analysis using the Pearson correlation coefficient, r. No significant correlations of ∆IOP1 between fellow eyes were found regardless of the number of IOP measurements. ∆IOP2 was significantly correlated between fellow eyes using two post-treatment IOP measurements, but not with a single post-treatment IOP. Using multiple post-treatment IOP measurements may improve the prediction of a fellow eye's response to glaucoma medication in one-eye trials.