Abstract
The purpose of the present investigation is to develop and characterize Acyclovir oral suspension in which Acyclovir is present in nanoparticle form manufactured using chitosan through ionic gelation method and test oral bioavailability in Rats. Methods of manufacturing and characterization of Chitosan nanoparticles of acyclovir was previously discussed. In continuation to earlier research work acyclovir nanoparticles were incorporated in oral suspension dosage form. Finished oral nanosuspension was characterized and pharmacokinetic parameters were studied in Rats. Pharmacokinetic parameters of nano suspension were compared with pharmacokinetic parameters of marketed suspension. Improvement in Cmax and AUC values revealed improvement in absorption of acyclovir in Rats.
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