Improved Outcome in Unexplained Repeated IVF Failures After Immunotherapy With Intravenous Immunoglobulin[IVIg] and AntiTNFalpha Drugs

Abstract

The most common reason that IVF is unsuccessful is the failure of embryos to implant.Although embryo abnormality may be responsible in many cases, problems relating to abnormalities in a woman’s immune system may play a part in a significant proportion of these failures. Evidence is emerging that immunologic and immunophenotypic evidence of local and peripheral natural killer[NK] cell activation and T-helper 1[TH1] dominance may be associated with unexplained repeated embryo implantation failure.We have identified women with these problems and treated them with what we consider appropriate immunotherapy.We present our findings.