Abstract
Surface treatment and bioactive metal ion incorporation are effective methods for the modification of titanium alloys to be used as biomaterials. However, few studies have demonstrated the use of air-plasma treatment in orthopedic biomaterial development. Additionally, no study has performed a direct comparison between unmodified titanium alloys and air-plasma-treated alloys with respect to their biocompatibility and osteogenesis. In this study, the biological activities of unmodified titanium alloys, air-plasma-treated titanium alloys, and air-plasma-treated strontium-doped/undoped calcium phosphate (CaP) coatings were compared. The strontium-doped CaP (Sr-CaP) coating on titanium alloys were produced by selective laser melting (SLM) technology as well as micro-arc oxidation (MAO) and air-plasma treatment. The results revealed that rapid air-plasma treatment improved the biocompatibility of titanium alloys and that Sr-CaP coating together with air-plasma treatment significantly enhanced both the biocompatibility and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). Overall, this study demonstrated that low temperature air-plasma treatment is a fast and effective surface modification which improves the biocompatibility of titanium alloys. Additionally, air-plasma-treated Sr-CaP coatings have numerous practical applications and may provide researchers with new tools to assist in the development of orthopedic implants.
Highlights
Titanium alloys are widely used as orthopedic implants for bone defects but the lack of osseointegration is a barrier to their application
The morphological features of the coated titanium alloy samples were characterized by scanning electron microscope (SEM)
To investigate the biocompatibility and osteogenesis of the coating, Rabbit bone marrow stromal cells (rBMSCs) were cultured on the coating surface and various assays were performed to determine the suitability of the coatings
Summary
Titanium alloys are widely used as orthopedic implants for bone defects but the lack of osseointegration is a barrier to their application. Air-plasma treatment has been implemented to improve the surface properties of biomaterials used in tissue engineering and drug delivery (Yoo et al, 2009; D’Sa et al, 2010; Chen et al, 2019). Various reports have demonstrated the enhanced biocompatibility of surfaces modified with air-plasma treatment (Liu et al, 2005; Lu et al, 2012). Jeong et al reported that the hydrophilicity of the amine plasma-treated titanium alloy plate was increased relative to the control. They suggest that this treatment had a positive effect on biocompatibility (Jeong et al, 2019). Previous studies demonstrated that air-plasma treatment significantly improved the biocompatibility of biomaterial surfaces in a quick and efficient manner
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
