Abstract
Quercetin, a substance from nature has various biological effects; while, some challenges like low solubility in water and absorption, and high first-pass metabolism hindered its clinical efficiencies. So, various strategies using novel nanocarriers have been designed to overcome these obstacles. This study aimed to fabricate the polymeric niosomes by incorporating hyaluronic acid to deliver quercetin. After preparation, quercetin entrapped niosomes were investigated in terms of size, zeta potential, quercetin entrapment, CTAB turbidimetric assay, AFM, TEM, differential scanning Calorimetry, X-Ray diffraction, DPPH antioxidant determination, and in vivo anti-inflammatory analysis. The analysis of the results exhibited that size of niosomes containing quercetin and hyaluronic acid was 231.07 ± 8.39 nm with a zeta potential of −34.00 ± 0.95 mV. Moreover, quercetin entrapment efficiency and loading were 94.67 ± 1.62% and 1.65 ± 0.37%, respectively. TEM and AFM showed that polymeric niosomes were spheres. The release data presented that the Higuchi model was the best-fitted model. DPPH antioxidant determination displayed that 80 µl of polymeric niosomes with 7.46 × 10−8 mol of quercetin had a remarkable antioxidant potency. According to the in vivo oedema evaluation, the potency of polymeric formulations was superior to the simple suspension of quercetin to control inflammation in rats by oral administration.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
