Improved muscle activation using proximal nerve stimulation with subthreshold current pulses at kilohertz-frequency

Abstract

Objective. Transcutaneous electrical nerve stimulation can help individuals with neurological disorders to regain their motor function by activating muscles externally. However, conventional stimulation technique often induces near-simultaneous recruitment of muscle fibers, leading to twitch forces time-locked to the stimulation. Approach. To induce less synchronized activation of finger flexor muscles, we delivered clustered narrower pulses to the proximal segment of the median and ulnar nerves at a carrier frequency of either 10 kHz (with an 80 µs pulse width) or 7.14 kHz (with a 120 µs pulse width) (high-frequency mode, HF), and different clustered pulses were delivered at a frequency of 30 or 40 Hz. Conventional stimulation with pulse frequency of 30 or 40 Hz (low-frequency mode, LF) was used for comparison. With matched elicited muscle forces between the HF and LF modes, the force variation, the high-density electromyogram (EMG) signals recorded at the finger flexor muscles and stimulation-induced-pain levels were compared. Main results. The compound action potentials in the 10 kHz HF mode revealed a significant difference (i.e. a lower amplitude and area, and a wider duration) compared with the LF mode, indicating cancellations of asynchronized action potentials. A smaller fluctuation in the elicited forces in the 10 kHz mode further demonstrated the less synchronized activation of different motor units. These effects tended to be weaker in the 7.14 kHz HF condition. However, the levels of pain sensation was not reduced in the HF mode potentially due to the high charge density used in the HF mode. Our findings indicated that different nerve fibers were recruited asynchronously through summations of different numbers of subthreshold depolarizations in the HF mode. Significance. Compared with the LF mode, the HF mode stimulation was capable of activating the nerve fibers in a less synchronized way, which is more similar to the physiological activation pattern.