Abstract
Fisetin was encapsulated with cycloamylose (CA), an intermediate product of cyclodextrin glucanotransferase (CGTase; EC 2.4.1.19), which is known to produce cyclodextrin (CD). The molecular weight measurement of the cycloamylose-fisetin inclusion complex (CA-FST) confirmed that it contained fisetin and CA with a degree of polymerization (DP) of 9–18. The aqueous solubility of CA-FST was approximately 3700 times higher than that of fisetin, with a solubility of 37.1 mg/mL. CA-FST showed a stability of 97.9 % at 4 °C over 1 week. CA-FST dissolved in water exhibited about 80 % antioxidant activity compared to the same amount of fisetin dissolved in methanol. In the analysis of anti-inflammatory effects, CA-FST decreased cytokine expression more effectively than fisetin, indicating that CA encapsulation using CGTase could be an effective method for overcoming the limited solubility of fisetin.
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