Abstract
A fast and reliable isocratic high-performance liquid chromatographic method suitable for simultaneous determination of the main component and impurities in neomycin sulphate is elaborated. Neomycin B and the related substances are separated as their 2,4-dinitrophenyl derivatives on a Zorbax SIL column using 1,2- dichloroethane-heptane-methanol-water-diethylamine (790:15:55:3.6:1.5) as the eluent. The method is compared to the commonly used microbiological method for quantitating neomycin.
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