Abstract
An improved assembly of the Ciona intestinalis genome reveals that it contains non-canonical introns and that about 20% of Ciona genes reside in operons.
Highlights
The draft genome sequence of the ascidian Ciona intestinalis, along with associated gene models, has been a valuable research resource
The present model set is primarily based on cDNA evidence
A fraction of previous models not supported by paired expressed sequence tag (EST) were excluded from the KH model set
Summary
The draft genome sequence of the ascidian Ciona intestinalis, along with associated gene models, has been a valuable research resource. Vertebrates and tunicates have genomic similarities, reflecting their evolutionary relationship, and differences. Several annotations based on assembly versions 1 and 2 have been published [1,6,7], but the gene model predictions have not been systematically evaluated and, in practice, are often found to be inconsistent with the growing body of experimental cDNA-based sequence data. Since the initial publication of the draft genome, a wide variety and great depth of data useful for gene annotation has been accumulated, whose largescale integration into the annotation process would greatly improve the accuracy of the gene model set
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