Improved flusing pipe method for PICC infusion of amphotericin B

Abstract

Objective To discuss the impact on PICC infusion amphotericin B by improved flushing method. Methods A total of 20 patients with the treatment of amphotericin B were chosen as control group by convenience sampling method of time sequence from January 2011 to January 2013, while 15 patients with the treatment of amphotericin B were selected as experimental group from February 2013 to June 2014. The patients of control group underwent impulsive type flushing pipe with 5% glucose injection 10 ml before amphotericin B infusion, while the patients of experimental group received improved flushing method. We compared the length of PICC catheter indwelling time and rate of unplanned extubation caused by drug blocking. Results The length of PICC catheter indwelling time were(30.5±15.3) days in the control group and (97.5±35.9) days in the experimental group (t=-6.785, P<0.01); the rate of unplanned extubation because of drug blocking were 80.0% in the control group and 6.7% in the experimental group (χ2=18.453, P<0.01). Conclusions Improved flushing pipe method can effectively extend the PICC single catheter indwelling time and reduce rate of unplanned extubation caused by drug blocking. Key words: PICC; Amphotericin B; Flushing pipe