Abstract
We have evaluated a newly implemented optical stimulator in a fetal MEG system for effectiveness of eliciting fetal flash evoked response using 29 normal, low-risk fetuses. MEG recordings were performed with a 151 channel array conforming to the maternal abdomen. Interference from maternal and fetal heart was attenuated by orthogonal projection and stimulus events were averaged to improve SNR after rejection of data segments with fetal motion. The responses identified by visual examination of the averaged time courses were subjected to validation by a significance measure based on a bootstrap confidence interval computation. The second generation stimulator increased comfort and ease of placement between the maternal abdomen and sensor array while delivering greater optical power to the fetus. After discarding 2 measurements for excessive artifact, averaged evoked responses with good baseline above background noise levels were observed in 24 recordings resulting in a detection rate of 89%; 26% greater than previously reported by our group using a first generation stimulator. Use of the new fetal visual stimulation delivery system resulted in an increased detection rate of fetal flash evoked response and the bootstrap significance measure provided some validation of results.
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