Abstract
Abstract A method for extraction of dimetridazole is described which affords high percentage recoveries of the drug from samples of animal origin. Samples are homogenized with benzene in the presence of just enough aqueous base to insure conversion of all the drug to the free base form and yet obtain a single phase liquid extract. Polarographic analyses of samples spiked with 267 and 33.3 ppm drug showed average recoveries, respectively, of 88.2% (range, 70.5–99.2%) and 87.8% (range, 78.6–101%). The average coefficient of variation for detection of these levels of drug was 3.33%. Under assay conditions, 1 ppm dimetridazole in tissues could not be detected. Factors affecting extent of drug extraction are discussed.
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