Abstract
Purpose: This article was intended to improve the efficacy of alpha-lipoic acid (ALA) for appetite suppression by controlling the particle size and self-polymerization of ALA. Methods: ALA was fabricated into micro- and nanoparticles, and the efficacy and in vitro release were investigated. Because of the self-polymerization of ALA into poly[3-(n-butane carboxylic acid)propyl]disulfide (PBCPD) by processing heat, low-speed rotation comminution was used to control PBCPD content. Results: The ALA particle size initially decreased and then increased after 10 hours of nanocomminution, indicating aggregation related to PBCPD formation. The in vitro release of ALA was significantly reduced by the existence of PBCPD. Interestingly, the reduction was not followed by a decrease in efficacy. Alternatively, the food intake was significantly reduced by ALA particles containing more than 30 mol% PBCPD. Conclusions: When the particle size and self-polymerization of ALA were carefully controlled, the efficacy on appetite suppression could be superior to water-soluble ALA salt. The ALA particles might have a composite nanostructure of ALA and PBCPD.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.