Abstract
Clostridium difficile reporting is mandatory in England, numbers have increased since the mid-1990s with over 25 000 reported per year. At Imperial College Healthcare it was observed that isolation of C. difficile from stool did not always reflect clinical disease; particularly when testing was changedto detection of glutamate dehydrogenase (GDH) and the tcdB gene by PCR. Testing for C. difficile in liquid stools was not restricted. All positive patients were therefore reviewed to determine if they had C. difficile associated disease (CDAD).
Highlights
Introduction / objectives Clostridium difficile reporting is mandatory in England, numbers have increased since the mid-1990s with over 25 000 reported per year
At Imperial College Healthcare it was observed that isolation of C. difficile from stool did not always reflect clinical disease; when testing was changedto detection of glutamate dehydrogenase (GDH) and the tcdB gene by PCR
All positive patients were reviewed to determine if they had C. difficile associated disease (CDAD)
Summary
Improved diagnostic test for Clostridium difficile: clinical and infection control implications. From International Conference on Prevention & Infection Control (ICPIC 2011) Geneva, Switzerland. Introduction / objectives Clostridium difficile reporting is mandatory in England, numbers have increased since the mid-1990s with over 25 000 reported per year. At Imperial College Healthcare it was observed that isolation of C. difficile from stool did not always reflect clinical disease; when testing was changedto detection of glutamate dehydrogenase (GDH) and the tcdB gene by PCR. Testing for C. difficile in liquid stools was not restricted. All positive patients were reviewed to determine if they had C. difficile associated disease (CDAD)
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