Abstract
In this study, a photoacoustic microscopy (PAM) system based on a multifocal point (MFP) transducer was fabricated to produce a large depth-of-field tissue image. The customized MFP transducer has seven focal points, distributed along with the transducer’s axis, fabricated by separate spherically-focused surfaces. These surfaces generate distinct focal zones that are overlapped to extend the depth-of-field. This design allows extending the focal zone of 10 mm for the 11 MHz MFP transducer, which is a great improvement over the 0.48 mm focal zone of the 11 MHz single focal point (SFP) transducer. The PAM image penetration depths of a chicken-hemoglobin phantom using SFP and MFP transducers were measured as 5 mm and 8 mm, respectively. The significant increase in the PAM image-based penetration depth of the chicken-hemoglobin phantom was a result of using the customized MFP transducer.
Highlights
Of late, optical techniques have been used widely in biomedical imaging, which has improved the performance of in vivo diagnosis with high optical contrast [1,2]
The transducer developed from this polyvinylidene fluoride (PVDF) has a normal broad bandwidth
To evaluate the capability of transducers in photoacoustic microscopy (PAM) imaging, ex vivo experiments were conducted with both single focal point (SFP) and multifocal point (MFP) transducers
Summary
Optical techniques have been used widely in biomedical imaging, which has improved the performance of in vivo diagnosis with high optical contrast [1,2]. This approach produces strong light scattering effects and a low spatial resolution. PAM can image optical contrast beyond the existing depth limit for high-resolution optical imaging [14]. Many studies developed photoacoustic tomography by employing a short pulse to generate ultrasound waves in biological tissues; such techniques are used for in vivo biomedical imaging [1,15]
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