Abstract

As one of the most prevalent cancers among women worldwide, breast cancer has attracted the most attention by researchers. It has been verified that an accurate and early detection of breast cancer can increase the chances for the patients to take the right treatment plan and survive for a long time. Nowadays, numerous classification methods have been utilized for breast cancer diagnosis. However, most of these classification models have concentrated on maximum the classification accuracy, failed to take into account the unequal misclassification costs for the breast cancer diagnosis. To the best of our knowledge, misclassifying the cancerous patient as non-cancerous has much higher cost compared to misclassifying the non-cancerous as cancerous. Consequently, in order to tackle this deficiency and further improve the classification accuracy of the breast cancer diagnosis, we propose an improved cost-sensitive support vector machine classifier (ICS-SVM) for the diagnosis of breast cancer. In the proposed approach, we take full account of unequal misclassification costs of breast cancer intelligent diagnosis and provide more reasonable results over previous works and conventional classification models. To evaluate the performance of the proposed approach, Wisconsin Breast Cancer (WBC) and Wisconsin Diagnostic Breast Cancer (WDBC) breast cancer datasets obtained from the University of California at Irvine (UCI) machine learning repository have been studied. The experimental results demonstrate that the proposed hybrid algorithm outperforms all the existing methods. Promisingly, the proposed method can be regarded as a useful clinical tool for breast cancer diagnosis and could also be applied to other illness diagnosis.

Highlights

  • Breast cancer is one of the most prevalent cancers among women all over the world [1, 2]

  • In order to overcome this deficiency, in this work we proposed an improved cost-sensitive support vector machine (ICS-Support Vector Machine (SVM)) classifier for breast cancer diagnosis, which employs information gain (IG) to select the optimal input feature, which is set to maximize the discrimination capability and fed the selected optimal feature subset into the improved CS-SVM classifier performing for classification

  • In 2017, Rasti et al proposed mixture ensemble of convolutional neural networks (ME-CNN) to discriminate between benign and malignant breast tumors, and the experimental results demonstrated that the proposed approach achieved an accuracy of 96.39%, a sensitivity of 97.73%, and a specificity of 94.87%, which has competitive classification performances compared to three existing single-classifier methods and two convolutional ensemble methods [2]

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Summary

Introduction

Breast cancer is one of the most prevalent cancers among women all over the world [1, 2]. In China, breast cancer was listed the sixth leading cause of death among women, and it has been estimated that 214,360 women had died from breast cancer by 2008, and the number of death will reach up to 2.5 million by 2021 [4]. It has been verified that an early detection of breast cancer can greatly increase the chances of taking the right decision on a successful treatment plan and ensure a longterm surviving for the patients [5] increased attention should be paid to the choice of diagnosis method for the breast cancer. It is absolutely necessary to develop a reasonable scientific method to distinguish malignant lesions from breast tumor lesions

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