Abstract
BackgroundThe aim of the present investigation was to improve comprehensive analytical method for the assessment of satranidazole in drug and product with simple, economic, sensitive, and reproducible spectrophotometric method. The drug was analyzed in three different methods by using various solvents where satranidazole (STZ) showed different absorbance maxima (s) and sharp peaks in the first order derivative spectra. Beer’s law range, correlation coefficient, apparent molar absorptivity, etc., were determined for each solvent using all the three methods.ResultsAll the results of analysis were found to be satisfactory which was validated statistically for various parameters and by performing recovery studies in accordance with international conference on harmonization (ICH) guidelines. The developed methods were also compared statistically using one way analysis of variance (ANOVA).ConclusionThree different spectrophotometric methods were developed for satranidazole (STZ) using various inorganic and organic solvents. The analytical methods are found to be simple, sensitive, rapid, specific, and economic, and it can be conveniently employed for the routine analysis, quality control. The sample recoveries from the formulation were in good agreement with its respective label claim.
Highlights
The aim of the present investigation was to improve comprehensive analytical method for the assessment of satranidazole in drug and product with simple, economic, sensitive, and reproducible spectrophotometric method
Satranidazole (STZ) is a new drug in the class of nitroimidazole derivative compounds. It is chemically known as 1-methylsulfonyl-3-(1-methyl-5-nitro-2-imidazolyl)-2imidazolidinone and therapeutically is a potential antibacterial and antiprotozoal which used management of amoebiasis [1]
Polar solvents are of two types: polar protic and polar aprotic, and they are named as such depending on their dissolution mechanism
Summary
The aim of the present investigation was to improve comprehensive analytical method for the assessment of satranidazole in drug and product with simple, economic, sensitive, and reproducible spectrophotometric method. The drug was analyzed in three different methods by using various solvents where satranidazole (STZ) showed different absorbance maxima (s) and sharp peaks in the first order derivative spectra. Satranidazole (STZ) is a new drug in the class of nitroimidazole derivative compounds. It is chemically known as 1-methylsulfonyl-3-(1-methyl-5-nitro-2-imidazolyl)-2imidazolidinone and therapeutically is a potential antibacterial and antiprotozoal which used management of amoebiasis [1]. Polar solvents are of two types: polar protic and polar aprotic, and they are named as such depending on their dissolution mechanism. The former one uses H bonding where the latter one uses a high “di pole-di pole” interface for solubilization. Solvents found giving peaks in the near UV region were corrected via resetting the scanning range with suitable lower limit
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