Abstract
The increasing prevalence of myopia has attracted global attention recently. Linear lesions including lacquer cracks and myopic stretch lines are the main signs in high myopia retinas, and can be revealed by indocyanine green angiography (ICGA). Automatic linear lesion segmentation in ICGA images can help doctors diagnose and analyze high myopia quantitatively. To achieve accurate segmentation of linear lesions, an improved conditional generative adversarial network (cGAN) based method is proposed. A new partial densely connected network is adopted as the generator of cGAN to encourage the reuse of features and make the network time-saving. Dice loss and weighted binary cross-entropy loss are added to solve the data imbalance problem. Experiments on our data set indicated that the proposed network achieved better performance compared to other networks.
Highlights
High myopia is a major cause of visual impairment and has rapidly increased in prevalence over the past 50 years
Intersection over union (IoU), known as Jaccard index, is the main metric which measures the overlap between the ground truth and segmentation results [15]
U-Net with partial dense connections are added in the comparison. It performs better than original U-Net, PSPNet and TiramisuNet, which indicates that the U-Net with partial dense connections can improve the performance of generator, and represents the proposed method is good at linear lesion segmentation even without conditional generative adversarial network (cGAN) mechanism
Summary
High myopia is a major cause of visual impairment and has rapidly increased in prevalence over the past 50 years. 10% develop myopia macular degeneration (MMD), which is the most common cause of visual impairment [2]. Linear lesions are main signs of MMD and important indicators of the progress of high myopia. Lacquer cracks and myopic stretch lines are two main types of linear lesions in pathological myopic eyes [3]. Lacquer cracks, having the prevalence of 4.3%-9.2% in highly myopic eyes [4,5], are believed to be breaks in the Bruch membrane-retinal pigment epithelium (RPE)-choriocapillaris complex owing to excessive axial elongation [6,7]. Myopic stretch lines are considered to be the precursors of lacquer cracks [8]
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