Abstract
Elevated serum CPK activity is an extremely sensitive index of acute myocardial infarction, but false positives occur with a frequency of around 15%. (1) CPK exists as three isoenzymes, MM, MB and BB, analysis of which should enhance diagnostic specificity. Until recently, quantification of individual serum CPK isoenzyme activity was inadequate due to imprecision in assay procedures. Recently, we have described a kinetic and fluorometric assay which is linear with respect to time and isoenzyme activity, having a sensitivity of .001 IU/ml with reproducibility ± 3%. (2) Utilizing this assay, the present study was designed to determine the sensitivity and specificity of serum CPK isoenzymes in the diagnosis of myocardial infarction.
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