Abstract

Improved Beta-Cell Function and Altered Plasma Levels of GLP-1 During OMTT and Fasting Following Bariatric Surgery in Women with NGT

Highlights

  • Obesity is increasing worldwide, associated with the epidemic increase in Type 2 Diabetes (T2D), and constitutes a leading cause of global morbidity and mortality, placing an enormous burden on healthcare systems

  • Studies on patients with Normal Glucose Tolerance (NGT) are relatively few, and a clear consensus is still lacking in terms of potential effects of bariatric surgery on fasting Glucagon-Like Peptide-1 (GLP-1) levels in obese subjects with NGT

  • Increased endogenous Glucagon-Like Peptide-1 (GLP-1) signaling has been considered a primary pathway leading to postsurgical weight loss and improvements in glucose metabolism following Vertical Sleeve Gastrectomy (VSG) and RYGB

Read more

Summary

Introduction

Obesity is increasing worldwide, associated with the epidemic increase in Type 2 Diabetes (T2D), and constitutes a leading cause of global morbidity and mortality, placing an enormous burden on healthcare systems. Increased endogenous Glucagon-Like Peptide-1 (GLP-1) signaling has been considered a primary pathway leading to postsurgical weight loss and improvements in glucose metabolism following VSG and RYGB. Most studies demonstrate similar postprandial increases in active GLP-1 following both procedures [11,12,13]. Many of these studies include patients with T2D or Impaired Glucose Tolerance (IGT), complicating the interpretation of the results, bariatric surgery is consistently associated with increased postprandial GLP-1 among individuals with NGT. Potential effects of bariatric surgery on fasting plasma GLP-1 levels in non-diabetic subjects remain elusive, and so the effects of surgical procedure/potential gender differences. In a recent meta-analysis designed to assess fasting GLP-1 levels after RYGB, 15 studies were included and no significant difference between preoperative and postoperative fasting plasma GLP-1 levels was detected [14]

Methods
Results
Discussion
Conclusion
Full Text
Paper version not known

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call