Improved antibacterial activities of coumarin antibiotics bearing 5′,5′-dialkylnoviose: biological activity of RU79115

Abstract

A new series of coumarin inhibitors of DNA gyrase B bearing a N-propargyloxycarbamate at C-3′ of various 5′,5′-dialkylnoviose, including RU79115, were synthesised and their antibacterial activities have been delineated. Introduction of dialkyl substituents at 5′5′-position of noviose leads to coumarin analogues with improved in vitro and in vivo antibacterial activity.