Improved and residual functional abnormalities in major depressive disorder after electroconvulsive therapy

Abstract

Electroconvulsive therapy (ECT) can induce fast remission of depression but still retain the residual functional impairments in major depressive disorder (MDD) patients. To delineate the different functional circuits of effective antidepressant treatment and residual functional impairments is able to better guide clinical therapy for depression. Herein, voxel-level whole brain functional connectivity homogeneity (FcHo), functional connectivity, multivariate pattern classification approaches were applied to reveal the specific circuits for treatment response and residual impairments in MDD patients after ECT. Increased FcHo values in right dorsomedial prefrontal cortex (dmPFC) and left angular gyrus (AG) and their corresponding functional connectivities between dmPFC and right AG, dorsolateral prefrontal cortex (dlPFC), superior frontal gyrus, precuneus (Pcu) and between left AG with dlPFC, bilateral AG, and left ventrolateral prefrontal cortex in MDD patients after ECT. Moreover, we found decreased FcHo values in left middle occipital gyrus (MOG) and lingual gyrus (LG) and decreased functional connectivities between MOG and dorsal postcentral gyrus (PCG) and between LG and middle PCG/anterior superior parietal lobule in MDD patients before and after ECT compared to healthy controls (HCs). The increased or normalized FcHo and functional connections may be related to effective antidepressant therapy, and the decreased FcHo and functional connectivities may account for the residual functional impairments in MDD patients after ECT. The different change patterns in MDD after ECT indicated a specific brain circuit supporting fast remission of depression, which was supported by the following multivariate pattern classification analyses. Finally, we found that the changed FcHo in dmPFC was correlated with changed depression scores. These results revealed a specific functional circuit supporting antidepressant effects of ECT and neuroanatomical basis for residual functional impairments. Our findings also highlighted the key role of dmPFC in antidepressant and will provide an important reference for depression treatment.