Abstract
Background Meiotic crossingover is an important checkpoint in almost all sexually reproducing eukaryotic organisms and is mediated by the Synaptonemal Complex (SC) during meiosis I. In this process homologous chromosomes exchange sequence information before segregating [1]. Some proteins involved in this process (i.e SYCP3) contain a conserved COR1 domain of which the function is not known, however; these proteins tend to be present only in germ cells [1-4].Xlr3 (X-linked lymphocyte regulated 3), an X-linked imprinted gene in mouse, also contains a COR1 domain but has yet to be characterized.
Highlights
Meiotic crossingover is an important checkpoint in almost all sexually reproducing eukaryotic organisms and is mediated by the Synaptonemal Complex (SC) during meiosis I
XLR3 localizes to the inactive X and Y chromosome during the pachytene stage of spermatogenesis
A second transient localization of XLR3 is seen at the post-meiotic repressed sex chromosomes (PMSC) in haploid round spermatids
Summary
Imprinted Xlr (X-linked Lymphocyte Regulated 3) produces a meiosis specific protein implicated in sex chromosome gene regulation in mouse. Robert J Foley1*, Seth Kasowitz, Emily Clancy, Andrew Sadowski, Michael O’Neill. From Epigenetics and Chromatin: Interactions and processes Boston, MA, USA. From Epigenetics and Chromatin: Interactions and processes Boston, MA, USA. 11-13 March 2013
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
