Abstract
Knowledge of the disease-specific genetic mutations in malignant pleural mesothelioma (MPM) has the potential to lead to rational targeted therapies. Recent studies have reported previously unknown recurrent genetic alterations in the BAP1 and LATS2 genes. Additional work has increased our understanding of the mechanism by which inactivating mutations in NF2 cause tumorigenesis. This review will highlight these recent discoveries and their relevance to MPM therapeutics.
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