Abstract
Severe scarring is a common and significant problem for burn patients who may have recovered from a life-threatening injury only to development severe hypertrophic scarring (HTS) after discharge from hospital, which significantly compromises their function, appearance, and quality of life. The clinical features of HTS, their assessment and measurement after burn injury are outlined. The cellular and molecular features of HTS are presented to assist the clinician’s understanding of the basis for prevention and treatment of HTS post-burn injury. Current therapies based on the pathophysiology of HTS are presented including conservative nonoperative approaches before surgical treatment and newly developing modalities are outlined.
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