Abstract

Introduction: Hypersensitivity pneumonitis, most frequent types are those related to farming and bird breeding. In this paper, a patient with occupational exposure to metal dusts and welding fumes but diagnosed with HP thanks to the guidance of detailed anamnesis revealing inhalational exposure to pigeon antigens both at home and in workplace Case: 32-year-old male. He applied with shortness of breath, dry cough. He has been working production of kitchen equipment made from stainless steel. When environmental exposures questioned, he declared that he bred up to ten pigeons at the basement of his house and up to fifteen pigeons at a coop next to workplace building. Spirometry revealed restrictive pattern. In patient’s chest X-ray, bilateral increased reticular densities were observed. Computed tomography of thorax revealed radiological findings supporting subacute hypersensitivity pneumonitis such as bilateral diffuse millimetric centrilobular ground-glass nodules which are coalescing in some areas, mosaic perfusion and air trapping in basal areas. Bronchoalveolar lavage cytology revealed percentages of lymphocytes as 85%. Discussion: Detailed anamnesis revealing environmental and occupational inhalational exposures guides the physician in diagnosis of HP. After initial suspicion, supporting laboratory and radiologic findings confirm the diagnosis to provide appropriate management.

Highlights

  • Hypersensitivity pneumonitis (HP), formerly called extrinsic allergic alveolitis, occurs as a result of nonIgE related type IV hypersensitivity reaction against various types of agents, namely antigens or chemicals, exposed environmentally or occupationally [1]

  • A detailed medical history is an essential part of the evaluation a patient for differential diagnosis of HP

  • Exposure history and typical high-resolution computed tomography (HRCT) findings along with lymphocyte predominant bronchoalveolar lavage (BAL) cytology are accepted as sufficient for confident clinical diagnosis for HP [6]

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Summary

A B ST R AC T

Hypersensitivity pneumonitis occurs in lungs as a result of type IV hypersensitivity reaction against various types of antigens sourced from animals, plants, fungi, bacteria, or low-molecular-weight chemical agents including isocyanates or metal fumes. Previous treatments for respiratory infections and asthma suggested by another center had failed. He was consulted to our occupational disease’s unit for any possible occupational lung disease including pneumoconiosis, due to his employment in production of stainless-steel kitchen equipment. Detailed anamnesis revealed that the patient was a pigeon breeder. Combining both detailed anamnesis of relevant exposures and supporting findings in high-resolution computed tomography of the chest and bronchoalveolar lavage cytology, the patient was diagnosed as hypersensitivity pneumonitis in collaboration with our hospital’s multidisciplinary team for pulmonary diseases. Received: July 2020, Accepted: July 2020, Published online: 30 September 2020

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