Abstract
Finland has the highest incidence of type 1 diabetes in the world, which has led to many important studies of type 1 diabetes in the Finnish population and to the formation of several study groups. In The Lancet Diabetes & Endocrinology, Minna Harsunen and colleagues 1 Harsunen M Haukka J Harjutsalo V et al. Residual insulin secretion in individuals with type 1 diabetes in Finland: longitudinal and cross-sectional analyses. Lancet Diabetes Endocrinol. 2023; (published online June 5.)https://doi.org/10.1016/S2213-8587(23)00123-7 Google Scholar present longitudinal and cross-sectional analyses of random C-peptide (an index of insulin secretion and β-cell function) measurements in three Finnish cohorts: 957 newly diagnosed patients seen at Helsinki University Hospital, in collaboration with the Finnish Pediatric Diabetes Registry (FPDR), for the longitudinal analysis; and 3984 study participants from the FinnDiane study group and 645 from the DIREVA regional diabetes registry in western Finland for the cross-sectional analysis. Data from these studies were used to examine which parameters were associated with residual insulin secretion. Residual insulin secretion in individuals with type 1 diabetes in Finland: longitudinal and cross-sectional analysesAlthough children with multiple autoantibodies and HLA risk genotypes progressed to absolute insulin deficiency rapidly, many adolescents and adults had residual random serum C-peptide decades after the diagnosis. Polygenic risk of type 1 and type 2 diabetes affected residual random serum C-peptide. Even low residual random serum C-peptide concentrations seemed to be associated with a beneficial complications profile. Full-Text PDF
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.